GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs7849270 | 1 | rs7869804 | chr9:131913144 | CRAT | chr9:131857075-131873070:- | 0.38 | 4.61 | 1.24E-5 | Blood metabolite ratios |
| THYM | cis | rs2243480 | 1 | rs78803505 | chr7:65382572 | CCT6P1 | chr7:65216092-65228661:+ | 0.67 | 4.9 | 3.88E-6 | Diabetic kidney disease |
| THYM | cis | rs6911965 | 1 | rs78808915 | chr6:24481312 | ALDH5A1 | chr6:24495197-24537434:+ | 0.33 | 4.16 | 7.04E-5 | Hematological and biochemical traits |
| THYM | cis | rs6911965 | 1 | rs78808915 | chr6:24481312 | GPLD1 | chr6:24428405-24489850:- | 0.56 | 5.51 | 3.04E-7 | Hematological and biochemical traits |
| THYM | cis | rs73726531 | 1 | rs78846846 | chr6:18132495 | NHLRC1 | chr6:18120718-18122851:- | -1.1 | -4.37 | 3.12E-5 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs12780845 | 1 | rs7894268 | chr10:17199830 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.8 | 5.85E-6 | Homocysteine levels |
| THYM | cis | rs7903456 | 1 | rs7903456 | chr10:88919319 | FAM35A | chr10:88854953-88951220:+ | -0.42 | -4.57 | 1.46E-5 | Renal underexcretion gout;Gout |
| THYM | cis | rs73726531 | 1 | rs79050301 | chr6:18152190 | NHLRC1 | chr6:18120718-18122851:- | -1.13 | -4.76 | 6.91E-6 | Thiopurine S-methyltransferase activity |
| THYM | cis | rs12780845 | 1 | rs7912093 | chr10:17203934 | CUBN | chr10:16865966-17171816:- | 0.31 | 4.8 | 5.85E-6 | Homocysteine levels |
| THYM | cis | rs975752 | 1 | rs7912631 | chr10:101915265 | BLOC1S2 | chr10:102033713-102046439:- | -0.5 | -5.35 | 6.1E-7 | Schizophrenia |
| THYM | cis | rs975752 | 1 | rs7915944 | chr10:101942253 | BLOC1S2 | chr10:102033713-102046439:- | -0.49 | -5.28 | 8.32E-7 | Schizophrenia |
| THYM | cis | rs1577917 | 1 | rs791856 | chr6:86681841 | SNHG5 | chr6:86386726-86388451:- | 0.57 | 7.62 | 1.9E-11 | Response to antipsychotic treatment |
| THYM | cis | rs2143950 | 1 | rs79199019 | chr14:35581125 | KIAA0391 | chr14:35591776-35786673:+ | 0.32 | 4.14 | 7.59E-5 | Atopic dermatitis |
| THYM | cis | rs2143950 | 1 | rs79199019 | chr14:35581125 | PPP2R3C | chr14:35554679-35591679:- | 0.27 | 4.99 | 2.76E-6 | Atopic dermatitis |
| THYM | cis | rs12780845 | 1 | rs7921162 | chr10:17229004 | CUBN | chr10:16865966-17171816:- | 0.3 | 4.53 | 1.71E-5 | Homocysteine levels |